Anti-SRP myopathy
نویسندگان
چکیده
منابع مشابه
Anti-SRP antibody-positive myopathy with universal alopecia and multiple vitiligo.
© 2015 The Authors. doi: 10.2340/00015555-1985 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 The signal recognition particle (SRP), an intracytoplasmic ribonucleoprotein complex of 6 polypeptides and a single 7SL RNA molecule, binds to the SRP receptor on the endoplasmic reticulum (1). Anti-SRP antibody is associated with a type of necrotising myopathy characterised by s...
متن کاملAnti-HMGCR Myopathy
Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy. After the discovery of anti-HMGCR autoantibodies, several international groups identified and characterized more patients, expanding the phenotypic spectrum of this disease to include pediatric patients and young adults without statin exposure and th...
متن کاملMyopathy with anti-HMGCR antibodies
Objective: To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody– associated myopathies. Methods: Retrospective review of records and myopathologic features of 49 consecutive patients with myopathies and serum HMGCR antibodies. Results: Clinical features included onset age from 1...
متن کاملPolymyositis anti-SRP antibodies and pregnancy about 2 cases
Anti-SRP myopathy represents 4 to 6% of all the inflammatory myopathies. It has been described since the 80s and its influence on pregnancy and vice versa has been highlighted recently. We report two cases of anti-SRP myopathy associated with pregnancy. In the first case, the initial manifestations of the disease started in post partum and the second case was an anti-SRP myopathy patient before...
متن کاملStatin-Induced Anti-HMGCR-Associated Myopathy.
In addition to self-limited myotoxicity, statins have recently been shown to trigger an immune-mediated necrotizing myopathy (IMNM), which is distinguished from polymyositis (PM) and dermatomyositis (DM) by the absence of primary inflammation on muscle biopsy. Previously, we have shown that patients with statin-associated necrotizing myopathy express an autoantibody targeting 3-hydroxy-3methylg...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2011
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.51.961